Dermatofibrosarcoma Protuberans Arising in a Digit: A Case Report
Division
West Florida
Hospital
Brandon Regional Hospital
Document Type
Case Report
Publication Date
2-19-2025
Keywords
Dermatofibrosarcoma protuberans, sarcoma, finger, tumor
Disciplines
Medicine and Health Sciences | Neoplasms | Pathology | Skin and Connective Tissue Diseases
Abstract
Dermatofibrosarcoma protuberans (DFSP) is a rare slow-growing soft tissue sarcoma that is usually found on the trunk or extremities. This report highlights an exceedingly rare case in which a DFSP arose on the digit of a 43-year-old man. Clinical and histologic analysis revealed an atypical CD34-positive tumor with differentials including DFSP and multiple similar entities. However, fluorescence in situ hybridization studies revealed a COL1A1 translocation to the platelet-derived growth factor B (22q13.1) locus, t(17;22)(q22;q13), confirming the diagnosis of DFSP. Although rare, this case highlights the importance of including DFSP on the differential in CD34-positive acral tumors, with cytogenetic analysis crucial for accurate diagnosis and treatment.
Publisher or Conference
The American Journal of Dermatopathology
Recommended Citation
Sun S, Odom J, Ruiz N, Moody P. Dermatofibrosarcoma Protuberans Arising in a Digit: A Case Report. Am J Dermatopathol. Published online February 19, 2025. doi:10.1097/DAD.0000000000002948