Tricyclic Antidepressant and Antipsychotic Toxicity: Clomipramine and Ziprasidone Overdose

Division

West Florida

Hospital

Brandon Regional Hospital

Document Type

Case Report

Publication Date

7-2-2024

Keywords

atypical antipsychotic, medical toxicology, tca toxicity, toxicology, toxicology and poisoning; tricyclic antidepressant, tricyclic antidepressant overdose, ziprasidone

Disciplines

Chemicals and Drugs | Emergency Medicine | Mental Disorders

Abstract

This case report details an intentional overdose attempt utilizing tricyclic antidepressants (TCAs) and atypical antipsychotics with significant neurologic, pulmonary, and cardiac toxicity. In conjunction with the local poison control center, progression of the clinical toxidrome was anticipated, aggressively managed, and successfully treated. This case highlights the dangers of significant TCA toxicity, peak onset of toxicity within six hours, and the amplification of clinical toxidromes with co-ingestions.

Publisher or Conference

Cureus

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