Ingestion of Isobutyl Nitrite Leading to Methemoglobinemia: A Case Report

Division

North Florida

Hospital

Osceola Regional Medical Center

Document Type

Case Report

Publication Date

11-21-2025

Keywords

amyl nitrite, cyano-methemoglobin pathway, methemoglobinemia, methylene blue, nitrite poisoning

Disciplines

Chemicals and Drugs | Emergency Medicine | Hemic and Lymphatic Diseases

Abstract

This case report highlights an occurrence of methemoglobinemia caused by the ingestion of liquid amyl nitrite, a substance often misused as a recreational drug. The patient in this case presented with cyanosis and elevated methemoglobin levels. Prompt administration of methylene blue successfully reversed the methemoglobinemia by reducing methemoglobin back to hemoglobin. This case emphasizes the importance of rapid diagnosis and treatment in nitrite-induced methemoglobinemia, demonstrating methylene blue as a highly effective antidote. It also highlights the risks associated with amyl nitrite misuse and the crucial role of healthcare providers in managing this potentially life-threatening condition.

Publisher or Conference

Cureus

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