Hydralazine-Induced Antineutrophilic Cytoplasmic Antibody (ANCA)-Associated Vasculitis Presenting as Crescentic Glomerulonephritis

Division

South Atlantic

Hospital

Orange Park Medical Center

Document Type

Case Report

Publication Date

4-26-2024

Keywords

anca-associated vasculitis (aav), hydralazine, necrotizing and crescentic glomerulonephritis, pauci-immune vasculitis, small vessel vasculitis

Disciplines

Cardiovascular Diseases | Internal Medicine | Medicine and Health Sciences

Abstract

Hydralazine is a vasodilator medication commonly used for treating hypertension. While generally well-tolerated, in rare cases it can induce autoimmune reactions, including anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. This case report presents a patient who developed ANCA-associated vasculitis resulting in crescentic glomerulonephritis (CrGN) following long-term hydralazine therapy, highlighting the importance of considering this rare adverse effect in patients with unexplained renal decline.

Publisher or Conference

Cureus

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