Response of FGFR-2 Positive Adenoid Cystic Carcinoma to Futibatinib: A Case Report.

Division

South Atlantic

Hospital

Orange Park Medical Center

Document Type

Case Report

Publication Date

6-27-2024

Keywords

adenoid cystic carcinoma (acc), fibroblast growth factor inhibitor, fibroblast growth factor receptor (fgfr), futibatinib, salivary gland tumor

Disciplines

Internal Medicine | Medicine and Health Sciences | Neoplasms

Abstract

Adenoid cystic carcinoma (ACC) is an uncommon and aggressive head and neck cancer mainly affecting minor salivary glands. It affects more women than men in their 60s and 70s. The tumor is typically locally aggressive and has a high rate of distant metastatic disease. This report unveils a potential avenue for targeted therapy for the management of metastatic disease: a patient with ACC who harbored a specific fibroblast growth factor receptor 2 (FGFR-2) mutation and responded significantly to a novel FGFR-2 inhibitor. This finding could pave the way for personalized treatment options for ACC patients with similar genetic alterations. Nevertheless, the use of futibatinib requires further investigation to optimize treatment protocols, including exploring combination therapies, identifying predictive biomarkers for treatment response, and developing strategies to overcome potential resistance.

Publisher or Conference

Cureus

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