"Steroid-refractory Lichenoid Eruption Associated with Pembrolizumab in a Patient with Non-small Cell Lung Cancer" by Leon Kou, Sanjay Agarwal et al.
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Scholarly Commons > HCA Healthcare Journal > Vol. 2 > Iss. 6 (2021)

 

Keywords

lichenoid eruption; pembrolizumab; PD-1 Inhibitors; drug side effects; methotrexate; steroid-refractory; non-small cell lung cancer

Disciplines

Dermatology | Medical Pharmacology | Oncology

Abstract

Programmed cell death receptor 1 (PD-1) inhibitors are promising and effective treatments for various cancers. Cutaneous adverse events, such as lichenoid drug eruptions, are well-known common side effects associated with PD-1 inhibitors. Lichenoid drug eruptions associated with PD-1 inhibitors show rapid improvement with high potency topical steroids and do not require cessation of the offending drug. We present the case of an 84-year-old female with progressive pembrolizumab therapy-associated lichenoid eruption that was resistant to several treatments and ultimately required discontinuation of pembrolizumab and treatment with methotrexate to resolve. This report includes histological findings of the pembrolizumab-associated lichenoid eruption.

Erratum

Pagination was incorrect. Page numbers have been corrected.

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