Presentation of Cutaneous Large B-Cell Lymphoma, Leg Type

Authors

Francisca I. Valenzuela, Corpus Christi Medical Center Bay AreaFollow
Michael R. Hohnadel, Corpus Christi Medical Center Bay AreaFollow

Keywords

B-cell lymphoma; hemic and lymphatic diseases; neoplasms; cutaneous B-cell lymphomas; aged

Disciplines

Hemic and Lymphatic Diseases

Abstract

A 91-year-old man presented with 2 violaceous, ulcerated plaques on his left lower leg, which developed over a 4-month period following a fall. The patient reported the initial formation of a solitary lump, which gradually enlarged and began bleeding a few weeks before his clinic visit. A histological examination of 2 biopsy samples revealed a dermal proliferation of large, severely atypical lymphoid cells with mitotic figures. Immunohistochemistry showed positivity for CD20, Bcl2, Bcl6, and MUM1, with cytokeratin 20 (CK20) negativity and a high percentage (80%-90%) of C-MYC positivity, which was consistent with a primary cutaneous diffuse large B-cell lymphoma (PCDLBC-LT). Given the findings, the patient was referred to oncology for further management.

Recommended Citation

Valenzuela, Francisca I. and Hohnadel, Michael R. (2025) "Presentation of Cutaneous Large B-Cell Lymphoma, Leg Type," HCA Healthcare Journal of Medicine: Vol. 6: Iss. 6, Article 5.
DOI: 10.36518/2689-0216.2006
Available at: https://scholarlycommons.hcahealthcare.com/hcahealthcarejournal/vol6/iss6/5