calciphylaxis; end-stage renal disease (ESRD); vascular calcification; calcific uraemic arteriolopathy; chronic kidney failure; renal failure; pain; skin ulcer


Dermatology | Diagnosis | Nephrology



Calciphylaxis is a rare disorder that involves the formation of cutaneous, subcutaneous, and vascular calcifications. Although it is predominantly seen in patients with end-stage renal disease (ESRD), it has also been reported in patients without chronic kidney disease. The presence of multiple risk factors, a poorly understood mechanism, high mortality, and the lack of standardized treatment make calciphylaxis an important subject.

Case Presentation

We describe the clinical presentation, disease course, and management of 3 patients with calciphylaxis and also provide a literature review. In all 3 patients, the diagnosis was confirmed histologically, and the management involved the continuation of renal replacement therapy, pain medication, wound debridement, and intravenous (IV) sodium thiosulphate.


Calciphylaxis should be suspected in ESRD patients presenting with painful areas of cutaneous induration, and the early recognition of these findings allows for prompt diagnosis and management.