Candidiasis; invasive; Candida glabrata; cervical spondylodiscitis; discitis; spondylitis
Infectious Disease | Internal Medicine | Neurosurgery
Invasive candidiasis can lead to numerous life-threatening sequelae. Candida glabrata is the second-most common causative species of invasive candidiasis. This species possesses a high risk for persistent infection and candidemia. An uncommon complication of invasive candidiasis is spondylodiscitis and can rarely affect the cervical spine.
The patient is a female in her late 50s with a complex medical history inclusive of chronic obstructive pulmonary disease, chronic pain, multiple abdominal surgeries, prolonged intensive care unit admission, and administration of total parenteral nutrition and broad-spectrum antibiotics who presented with complaints of worsening neck pain. She was last hospitalized 3 months prior and found to have C glabrata fungemia but was nonadherent to antifungal therapy.
She was found to have advanced C5-6 spondylodiscitis and an epidural abscess. Her surgical cultures grew C glabrata. Despite surgical intervention and antimicrobial therapy, she clinically deteriorated and acquired septic shock with multiorgan failure.
This is a rare case of cervical spondylodiscitis caused by a deep-seated C glabrata infection.
Hong, Angelina; Lim, Lily Hyungjung; Alvi, Ali Tariq; and Aneja, Pallavi
"A Rare Case of Candida glabrata Cervical Spondylodiscitis,"
HCA Healthcare Journal of Medicine: Vol. 4:
6, Article 5.
Available at: https://scholarlycommons.hcahealthcare.com/hcahealthcarejournal/vol4/iss6/5